ea0086oc6.2 | Thyroid | SFEBES2022
Zha Ling
, Brookes Katie
, Thornton Caitlin
, Fletcher Alice
, Kim Jana
, Sunassee Kavitha
, Blower Philip J
, Nieto Hannah R
, Smith Vicki E
, Read Martin L
, McCabe Christopher J
Background: The sodium/iodide symporter (NIS) frequently shows diminished targeting to the plasma membrane (PM) in differentiated thyroid cancer, resulting in suboptimal radioiodine treatment and poor prognosis. However, the mechanisms which govern the endocytosis of NIS away from the PM its sole site of transport activity are ill-defined, and may be of direct therapeutic potential. We previously showed that the proto-oncogene PBF binds NIS and enhances its inter...